MODERN IDEAS ABOUT THE PHYSIOLOGICAL MECHANISMS OF HUMORAL REGULATION OF THE LABOR PROCESS
DOI:
https://doi.org/10.32782/eddiscourses/2024-1-11Keywords:
humoral regulation, humoral factors, mechanisms of laborAbstract
Statistics on premature births vary from country to country and over time, but it remains a serious health problem. According to the World Health Organization, about 10% of pregnancies end in premature birth worldwide. This means that more than 1 in 10 babies are born prematurely. Premature birth is considered to occur before the 37th week of pregnancy. However, there are earlier cases when a child is born with underdeveloped organs and systems. Preterm birth accounts for most of the neonatal morbidity and mortality in developed countries. The article examines the physiological mechanisms of influence of widely known humoral factors of labor such as oxytocin, prostaglandins, estrogens, progesterone, relaxin, corticotropin-releasing hormone, and endothelial factors such as nitric oxide and endothelin. In addition, the participation of less studied factors regulating labor, such as 15-hydroxyprostaglandin dehydrogenase, human chorionic gonadotropin, active surfactant protein, fetal platelet activator, caspases, is considered. The analyzed factors expand the understanding of the multicomponent nature of labor inducers and the complexity of the humoral interaction between the fetus and the woman in labor. The processes of humoral regulation of periods of labor described in the article can potentially be used to counteract premature birth.
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