USE OF PHARMACOLOGICAL DATABASES FOR UNDERGRADUATE SCIENTIFIC EDUCATION OF STUDENTS OF MEDICAL AND PHARMACEUTICAL FACULTIES

Abstract

Relevance. The newest approach to the preparation of students at the master's level was the preparation of qualifying work by students. An important part of the preparation of this work is the analysis of current scientific research and the use of pharmacological databases for the analysis of pharmacokinetic and pharmacodynamic properties of medicinal products, assessment of dangerous side reactions. Objective: analysis of the possibilities of pharmacological data bases to increase the effectiveness of scientific research by students of the pharmaceutical, medical, pediatric and stomatological faculties. Methods. We used informational and analytical methods, as well as scientific research based on the well-known pharmacological databases "DrugBank", "LiverTox", "Hep Drug Interactions", "Covid-19 Drug Interactions" and "Cancer Drug Interactions" in undergraduate scientific education. Results. The "DrugBank" database is effective in conducting a thorough analysis of the pharmacokinetic and pharmacodynamic properties of medicinal products, studying new data on the pathogenesis of their adverse reactions. The "LiverTox" database can be useful for evaluating the hepatotoxicity of drugs. During the treatment of patients, the risks of developing cytolytic and cholestatic syndromes, the possibility of progression of liver fibrosis, and the development of acute liver failure are observed. The "Hep Drug Interactions" database allows you to quickly find options for safe interactions of drugs for the treatment of chronic viral hepatitis B, C, D. This allows you to conduct practical classes for students of pharmaceutical and medical faculties, which allow you to study safe schemes for the treatment of chronic liver pathology. The analysis of the possibility of prescribing anti-Covid drugs with proven etiotropic and pathogenetic efficacy with other groups of drugs retains its relevance. The analysis of dated protocols provided by the Liverpool database "Covid-19 Drug Interactions" significantly expands the possibilities of predicting adverse reactions during mass pharmacotherapy of COVID-19. When studying the dangerous interactions of chemotherapeutic drugs, the "Cancer Drug Interactions" database is useful, allowing to determine the boundaries of prescribed drugs of other groups during antitumor pharmacotherapy. The work includes examples of the successful use of pharmacological databases in the preparation of master's qualification and scientific theses of students, where new information about drug interactions is used in the study of real clinical material. Conclusions. In the training program of students of medical and pharmaceutical universities, it is expedient to include information on modern pharmacological databases: "DrugBank", "LiverTox", "Hep Drug Interactions", "Covid-19 Drug Interactions" and "Cancer Drug Interactions", which will significantly improve the level advanced scientific education.