ASSESSMENT OF THE CLINICAL SAFETY OF MEDICINES WHEN PRESCRIBED TO WOMEN DURING THE LACTATION PERIOD (USEFULNESS OF REVIEWED DATABASES)
DOI:
https://doi.org/10.32782/eddiscourses/2025-1-18Keywords:
clinical pharmacology, undergraduate scientific education, pharmacological databases, LactMed, E-LactanciaAbstract
Relevance. Information essential for future doctors and pharmacists regarding the effects of drugs on breastfeeding and infants remains insufficiently covered in undergraduate education. On the one hand, the benefits of breastfeeding are well-known, and according to WHO recommendations, every child should receive exclusive breastfeeding for a duration of 6 months to 2 years or more. On the other hand, mothers face obstacles to breastfeeding due to the marketing of commercial infant formulas and a lack of resources to support breastfeeding. The potential risks of drugs for breastfeeding mothers and their children, along with numerous often poorly substantiated materials, highlight the need for informative, peer-reviewed databases that can promptly provide comprehensive information to doctors and pharmacists.Objective. To analyze the possibilities of utilizing pharmacological databases to improve the quality of undergraduate education for students in pharmaceutical, medical, pediatric, and dental faculties concerning the potential risks of prescribing medications to breastfeeding women. Methods. The study employed an information-analytical method and incorporated the authors’ personal experience using pharmacological databases, particularly LactMed and E-Lactancia, in undergraduate education.Results and Discussion. A thorough analysis of the pharmacokinetic and pharmacodynamic properties of drugs and the acquisition of the latest data on the pathogenesis of their adverse effects in lactating women demonstrated the effectiveness of using the LactMed and E-Lactancia databases. The E-Lactancia database proves particularly useful for the rapid screening assessment of drugs for potential use by breastfeeding women during pharmaceutical care. Following an initial evaluation of a drug’s potential risks, pharmacists or physicians can conduct a more detailed analysis of its pharmacokinetic and pharmacodynamic properties in lactating women using the LactMed database. This database provides information on drug concentrations in breast milk, potential adverse effects in infants, and delayed consequences of drug use. The study proves the feasibility of a two-stage use of the LactMed and E-Lactancia pharmacological databases in analyzing the potential danger of drugs for women during lactation.Conclusions. It is advisable to include information on the modern pharmacological databases LactMed and E-Lactancia in the curricula of medical and pharmaceutical university students when teaching topics related to adverse drug reactions in lactating women.
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